Gene information
Official symbol CASP1
Official full name caspase 1
Gene type protein-coding gene
Chromosome11q22.3
Alias symbolICE
Previous symbolIL1BC
Gene familyCaspases; Caspase recruitment domain containing
Resources
Entrez Gene 834
HGNC HGNC:1499
Ensembl ENSG00000137752
Vega OTTHUMG00000048072
UCSC uc021qpp.3
GO terms: 38 records
GO Description Category LogP Number of genes Detail
GO:0001959 regulation of cytokine-mediated signaling pathway GO Biological Processes -13.0991884 33 More
GO:0002237 response to molecule of bacterial origin GO Biological Processes -48.4964960 93 More
GO:0006690 icosanoid metabolic process GO Biological Processes -21.0788451 23 More
GO:0006970 response to osmotic stress GO Biological Processes -4.47323224 7 More
GO:0009612 response to mechanical stimulus GO Biological Processes -18.7627330 44 More
GO:0009615 response to virus GO Biological Processes -11.2861143 47 More
GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway GO Biological Processes -3.24021630 5 More
GO:0010950 positive regulation of endopeptidase activity GO Biological Processes -13.2452311 34 More
GO:0010952 positive regulation of peptidase activity GO Biological Processes -14.1524623 37 More
GO:0016053 organic acid biosynthetic process GO Biological Processes -15.6178787 26 More
GO:0019900 kinase binding GO Molecular Functions -6.03057706 62 More
GO:0031347 regulation of defense response GO Biological Processes -64.5971043 148 More
GO:0031349 positive regulation of defense response GO Biological Processes -32.1301903 71 More
GO:0032103 positive regulation of response to external stimulus GO Biological Processes -58.7273809 118 More
GO:0032496 response to lipopolysaccharide GO Biological Processes -45.257773 87 More
GO:0032651 regulation of interleukin-1 beta production GO Biological Processes -19.7300517 34 More
GO:0032652 regulation of interleukin-1 production GO Biological Processes -24.2088254 41 More
GO:0034341 response to interferon-gamma GO Biological Processes -10.8524889 26 More
GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process GO Biological Processes -14.7594418 39 More
GO:0044283 small molecule biosynthetic process GO Biological Processes -16.6163676 33 More
GO:0046394 carboxylic acid biosynthetic process GO Biological Processes -15.6974044 26 More
GO:0046456 icosanoid biosynthetic process GO Biological Processes -13.7551761 13 More
GO:0050727 regulation of inflammatory response GO Biological Processes -68.5964592 121 More
GO:0050729 positive regulation of inflammatory response GO Biological Processes -38.1621935 57 More
GO:0051345 positive regulation of hydrolase activity GO Biological Processes -19.7369783 79 More
GO:0051607 defense response to virus GO Biological Processes -3.02916189 22 More
GO:0060759 regulation of response to cytokine stimulus GO Biological Processes -13.7003447 35 More
GO:0062197 cellular response to chemical stress GO Biological Processes -14.0979689 44 More
GO:0071214 cellular response to abiotic stimulus GO Biological Processes -11.2775864 23 More
GO:0071216 cellular response to biotic stimulus GO Biological Processes -28.1549742 59 More
GO:0071219 cellular response to molecule of bacterial origin GO Biological Processes -28.3848077 56 More
GO:0071222 cellular response to lipopolysaccharide GO Biological Processes -26.0381191 52 More
GO:0071260 cellular response to mechanical stimulus GO Biological Processes -11.7214175 13 More
GO:0071396 cellular response to lipid GO Biological Processes -37.0669488 98 More
GO:0071496 cellular response to external stimulus GO Biological Processes -17.0078490 52 More
GO:0104004 cellular response to environmental stimulus GO Biological Processes -11.2775864 23 More
GO:0140546 defense response to symbiont GO Biological Processes -3.00647654 22 More
GO:2000116 regulation of cysteine-type endopeptidase activity GO Biological Processes -14.4496812 41 More
KEGG pathways: 3 records
KEGG Description Category LogP Number of genes Detail
hsa04613 Neutrophil extracellular trap formation KEGG Pathway -12.8071279 20 More
hsa04625 C-type lectin receptor signaling pathway KEGG Pathway -5.36927089 9 More
hsa05135 Yersinia infection KEGG Pathway -7.02427022 12 More
Drug-Gene interaction
view
Related drugs: 23 records
Drug name Interaction type Source PMID View
4-chloromercuribenzoic acid DTC view
belnacasan TdgClinicalTrialTTD view
berkeleyacetal a DTC 17970594 view
berkeleyacetal b DTC 17970594 view
berkeleyacetal c DTC 17970594 view
berkeleyamide b DTC 18330993 view
berkeleyamide c DTC 18330993 view
berkeleydione DTC 17970594 view
berkeleytrione DTC 17970594 view
chembl337173 DTC view
chembl415893 DTC 10386941 view
chembl429095 DTC view
chembl578512 DTC view
chembl580421 DTC view
diacerein TTD view
emricasan inhibitor ChemblInteractions view
gossypol DTC view
isoboldine DTC view
juglone DTC view
mesalamine DTC view
nivocasan inhibitor ChemblInteractionsTTD view
pralnacasan inhibitor TTD 17845807 view
vermistatin DTC 22295871 view
Related study: 1 record
Molecular factor Omics type Application Objective MI type Reference
NC_000011.10:g.105029761G>A genomics late-acquired stent malapposition[prognosis (bad)] acute ST elevation myocardial infarction Bergheanu SC et al. Heart Vessels. 2011
All rights reserved: Soochow University Center for Systems Biology